Learning and Memory: Cellular Mechanisms

Nobel of the Week

  • 2000 - Arvid Carlsson, Paul Greengard and Eric R. Kandel "for their discoveries concerning signal transduction in the nervous system", focus on Greengard and Kandel.
  • 2014 - John O'Keefe, May-Britt Moser and Edvard I. Moser "for their discoveries of cells that constitute a positioning system in the brain".

    Introductory Readings for discussion on December 6.

  • Principles of Neuroscience (2013) Fifth Edition, eds. Kandel, ER, Schwartz, JH, Jessell, TM, Hudspeth, J. Chapters 65, 66, 67.

    Additional readings for discussion on December 6.

  • Scoville WB and Milner B (1957) Loss of recent memory after bilateral hippocampal lesions. J. Neurol. Neurosurg. Psychiat. 20:11-21.
  • Parker, ES, Cahill, L, McGaugh, JL (2006) A case of unusual autobiographical remembering. Neurocase 12: 35-49.
  • Morris RGM, Garrud P, Rawlins JNP, and O'Keefe J. (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297:681-683.

    Original Literature Readings for discussion on December 8.

  • Kandel ER and Schwartz JH (1982) Molecular biology of learning: Modulation of transmitter release. Science 218:433-443.
  • Bliss TVP, Collingridge (1993) A synaptic model of memory: long term potentiation in the hippocampus. Nature 361:31-39.
  • Chain DG, Casadio A, Schacher S, Hegde AN, Valbrun M, Yamamoto N, Goldberg AL, Bartsch D, Kandel ER and Schwartz JH (1999) Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia. Neuron 22:147-156.