SYSTEMS NEUROSCIENCE N623 - Week 16
Learning and Memory: Cellular Mechanisms
Nobel of the Week
2000 - Arvid Carlsson, Paul Greengard and Eric R. Kandel "for their discoveries concerning signal transduction in the nervous system", focus on Greengard and Kandel.
Introductory Readings for discussion on December 5.
Principles of Neuroscience (2000) eds. Kandel, ER, Schwartz, JH, and Jessell, TM. Chapter 62. Parker, ES, Cahill, L, McGaugh, JL (2006) A case of unusual autobiographical remembering. Neurocase 12: 35-49.
Additional readings for discussion on December 5.
Scoville WB and Milner B (1957) Loss of recent memory after bilateral hippocampal lesions. J. Neurol. Neurosurg. Psychiat. 20:11-21. Morris RGM, Garrud P, Rawlins JNP, and O'Keefe J. (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297:681-683.
Introductory Readings for discussion on December 8.
Principles of Neuroscience (2000) eds. Kandel, ER, Schwartz, JH, and Jessell, TM. Chapter 63.
Original Literature Readings for discussion on December 8.
Kandel ER and Schwartz JH (1982) Molecular biology of learning: Modulation of transmitter release. Science 218:433-443. Chain DG, Casadio A, Schacher S, Hegde AN, Valbrun M, Yamamoto N, Goldberg AL, Bartsch D, Kandel ER and Schwartz JH (1999) Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia. Neuron 22:147-156.
Original Literature Readings for discussion on May 12.
Drier EA, Tello MK, Cowan M, Wu P, Blace N, Sacktor TC, and Yin JCP (2002) Memory enhancement and formation by atypical PKM activity in Drosophila melanogaster. Nature Neurosci. 5:316-324. Lamprecht R, Hazvi S, and Dudai Y (1997) cAMP response element-binding protein in the amygdala is required for long- but not short-term conditioned taste aversion memory. J. Neurosci. 17:8443-8450. Bliss TVP, Collingridge (1993) A synaptic model of memory: long term potentiation in the hippocampus. Nature 361:31-39.