SYSTEMS NEUROSCIENCE N623 - Week 14
Learning and Memory: Cellular Mechanisms
Nobel of the Week
2000 - Arvid Carlsson, Paul Greengard and Eric R. Kandel "for their discoveries concerning signal transduction in the nervous system", focus on Greengard and Kandel. 2014 - John O'Keefe, May-Britt Moser and Edvard I. Moser "for their discoveries of cells that constitute a positioning system in the brain".
Introductory Readings for discussion on December 6.
Principles of Neuroscience (2013) Fifth Edition, eds. Kandel, ER, Schwartz, JH, Jessell, TM, Hudspeth, J. Chapters 65, 66, 67.
Additional readings for discussion on December 6.
Scoville WB and Milner B (1957) Loss of recent memory after bilateral hippocampal lesions. J. Neurol. Neurosurg. Psychiat. 20:11-21. Parker, ES, Cahill, L, McGaugh, JL (2006) A case of unusual autobiographical remembering. Neurocase 12: 35-49. Morris RGM, Garrud P, Rawlins JNP, and O'Keefe J. (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297:681-683.
Original Literature Readings for discussion on December 8.
Kandel ER and Schwartz JH (1982) Molecular biology of learning: Modulation of transmitter release. Science 218:433-443. Bliss TVP, Collingridge (1993) A synaptic model of memory: long term potentiation in the hippocampus. Nature 361:31-39. Chain DG, Casadio A, Schacher S, Hegde AN, Valbrun M, Yamamoto N, Goldberg AL, Bartsch D, Kandel ER and Schwartz JH (1999) Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia. Neuron 22:147-156.