SYSTEMS NEUROSCIENCE N623 - Week 10
Smell and Taste: The Chemical Senses
Nobel of the Week
2004 - Richard Axel and Linda B. Buck, "for their discoveries of odorant receptors and the organization of the olfactory system"
Introductory Readings for discussion on October 22.
Kandel, Schwartz, Jessell, Chapter 32.
Original Literature Readings for discussion on October 24.
Malnic, B, Hirono, J, Sato, T, and Buck, LB. (1999) Combinatorial receptor codes for odors. Cell 96:713-723. Iwema, CL, Fang, H, Kurtz, DB, Youngentob, SL, and Schwob, JE. (2004) Odorant receptor expression patterns are restored in lesion-recovered rat olfactory epithelium. J. Neurosci. 24:356-369. Kent, PF, Mozell, MM, Youngentob, SL, and Yurco, P. (2003) Mucosal activity patterns as a basis for olfactory discrimination: Comparing behavior and optical recordings. Brain Res. 981:1-11.
Original Literature Readings for discussion on October 27.
Mombaerts, P, Wang, F, Dulac, Chao, SK, Nemes, A, Mendelsohn, Edmonson, J, and Axel R. (1996) Visualizing an olfactory sensory map. Cell 87:675-686. Meister, M, and Bonhoeffer, T. (2001) Tuning and topography in an odor map on the rat olfactory bulb. J. Neurosci. 21:1351-1360. Johnson, BA, Ho, SL, Xu, Z, Yihan, JS, Yip, S, Hingco, EE, and Leon, M. (2002) Functional mapping if the rat olfactory bulb using diverse odorants reveals modular responses to functional groups and hydrocarbon structural features. J. Comp. Neurol. 449:180-194. Zou, Z, Horowitz, L, Montmayeur, JP, Snapper, Buck, L. (2001) Genetic tracing reveals a stereotyped sensory map in the olfactory cortex. Nature 414:173-179.