Sensory Experience, Plasticity and Reorganization

Introductory Readings for discussion on Dec 3.

Refresh your memory or read what material you have not yet been exposed to in other classes, N613, etc.
  • Principles of Neuroscience (2000) eds. Kandel, ER, Schwartz, JH, and Jessell, TM. Re-read Chapter 20, pages 384-393, and Figures 20-1 to 20-11.
  • Wiesel, TN (1981) The postnatal development of the visual cortex and the influence of environment. Nobel Lecture 12/8/1981.

    Quickie Demos

  • Perceptual fill-in of your blindspot.
  • Neon spreading.
  • More neon spreading.
  • Powerpoint of more blindspot and fill-in demos.

    Original Literature Readings for discussion on Dec 3.

  • Buonomano, DV and Merzenich, MM (1998) Cortical Plasticity: From Synapses to Maps. Annu. Rev. Neurosci. 21: 149-186.
  • Ramachandran (2000) Phantom limbs and neural plasticity. Arch. Neurol. 57: 317-320.
  • Gilbert, CD and Wiesel, TN (1992) Receptive field dynamics in adult primary visual cortex, Nature 356:150-152.
  • Darian-Smith, C and Gilbert, CD (1994) Axonal sprouting accompanies functional reorganization in adult cat striate cortex, Nature 368:737-740.
  • Smirnakis, S. M., A. A. Brewer, M. C. Schmid, A. S. Tolias, A. Schüz, M. Augath, W. Inhoffen, B. A. Wandell and N. K. Logothetis (2005) Lack of long-term cortical reorganization after macaque retinal lesions. Nature 435, 300-307. (You may skim this article.) [A rebuttal/exchange about this controversy.]

    Optional Readings

  • Darian-Smith and Gilbert (1995) Topographic reorganization in the striate cortex of the adult cat and monkey is cortically mediated. J. Neurosci. 15:1631-1647.
  • Kaas, Krubitzer, Chino, Langston, Polley and Blair (1990) Reorganization of retinotopic cortical maps in adult mammals after lesions of the retina, Science 248:229-231.
  • Baker, CI, Peli, E, Knouf, N, Kanwisher, NG. (2005) Reorganization of Visual Processing in Macular Degeneration J. Neurosci. 25: 614-618.
  • Florence, SL, Taub, HB, Kaas, JH (1998) Large-scale sprouting of cortical connections after peripheral injury in adult macaque monkeys. Science 282: 1117-1121.
  • Jones, EG, Pons, TP (1998) Thalamic and brainstem contributions to large-scale plasticity of primate somatosensory cortex. Science 282: 1117-1121.
  • Recanzone (2000) Cerebral cortical plasticity: Perception and skill acquisition, In: The New Cognitive Neuroscience, MS Gazzaniga, ed. 237-247.
  • Ramachandran (1993) Behavioral and magnetoencephalographic correlates of plasticity in the adult human brain. PNAS 90:10413-10430.
  • Moore, CI, Stern, CE, Dunbar, C, Kostyk, SK, Gehi, A, Corkin , S. (2000) Referred phantom sensations and cortical reorganization after spinal cord injury in humans. PNAS 97: 14703-14708.

    Original Literature Readings for discussion on Dec 17.

  • Knudsen EI. (2002) Instructed learning in the auditory localization pathway of the barn owl. Nature 417: 322-328.
  • Polley, DB, Steinberg, EE, Merzenich, MM. (2006) Perceptual learning directs auditory cortical map reorganization through top-down influences. J. Neurosci. 26: 4970-4982.
  • Rauschecker, JP (1995) Compensatory plasticity and sensory substitution in the cerebral cortex. TINS 18: 36-43.
  • Cohen, LG, Celnik, P, Pascual-Leone, A, Corwell, B, Faiz, L, Dambrosia, J, Honda, M, Sadato, N, Gerloff, C, Catala´, MD, Hallett, M. (1997) Functional relevance of cross-modal plasticity in blind humans. Nature 389:180-183.

    Optional Readings

  • Gould, E, Reeves, AJ, Graziano, MSA, Gross, CG (1999) Neurogenesis in the neocortex of adult primates. Science 286: 548-552.
  • Doupe, AJ and Kuhl, PK (1999) Birdsong and human speech: Common themes and mechanisms. Annu. Rev. Neurosci. 22: 567-631.
  • Knudsen and Brainard (1991) Visual instruction of the neural map of auditory space in the developing optic tectum, Science 253:85-87.
  • Brainard and Knudsen (1993) Experience-dependent plasticity in the inferior colliculus: A site for visual calibration of the neural representation of auditory space in the barn owl, J. Neurosci. 13:4589-4608.
  • Hyde PS, Knudsen EI (2002) The optic tectum controls visually guided adaptive plasticity in the owl's auditory space map. Nature 415: 73-76.
  • Recanzone, GH (1998) Rapidly induced auditory plasticity: The ventriloquism aftereffect. PNAS 95(3): 869 - 875.
  • Schwab, ME (2002) Repairing the injured spinal cord. Science 295: 1029-1031.
  • Woolf, CJ, Salter, MW (2000) Neuronal Plasticity: Increasing the gain in pain. Science 288:1765-1768.
  • Rakic, P, Suner, I, and Williams, RW (1991) A Novel Cytoarchitectonic Area Induced Experimentally Within the Primate Visual Cortex. PNAS 88: 2083-2087.
  • Kahn, DM and Krubitzer, L. (2002) Massive cross-modal cortical plasticity and the emergence of a new cortical area in developmentally blind mammals. PNAS 99(17): 11429 - 11434.
  • Rakic, P (1985) Limits of neurogenesis in primates. Science 227: 1054-1056.
  • Gould, E, Reeves, AJ, Graziano, MSA, Gross, CG (1999) Neurogenesis in the neocortex of adult primates. Science 286: 548-552.
  • Von Melchner, L., Pallas, S.L. and Sur, M. (2000) Visual behavior mediated by retinal projections directed to the auditory pathway. Nature 404:871-876.