SYSTEMS NEUROSCIENCE N623 - Week 13
Nobel of the Week
2000 - Arvid Carlsson, Paul Greengard and Eric R. Kandel "for their discoveries concerning signal transduction in the nervous system", focus on Carlsson.
Introductory Readings for discussion on November 17.
Principles of Neuroscience (2000) eds. Kandel, ER, Schwartz, JH, and Jessell, TM. Chapter 43.
Additional background reading - highly relevant to information presented in class:
Alexander GE, DeLong MR, Strick PL (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9:357-381. Middleton FA (2002) Fundamental and clinical evidence for basal ganglia influences on cognition. In: Mental and Behavioral Dysfunction in Movement Disorders (M.A. Bedard et al., Eds), pp. 13-33, Human Press., Totowa, NJ.
Original Literature Readings for discussion on November 17.
Crutcher MD, DeLong MR (1984) Single cell studies of the primate putamen. I. Functional organization. Exp Brain Res 53:233-43. Crutcher MD, DeLong MR (1984) Single cell studies of the primate putamen. II. Relations to direction of movement and pattern of muscular activity. Exp Brain Res. 53:244-58. DeLong MR, Crutcher MD, Georgopoulos AP (1985) Primate globus pallidus and subthalamic nucleus: functional organization. J Neurophysiol. 53:530-43. Hikosaka O, Wurtz RH (1983) Visual and oculomotor functions of monkey substantia nigra pars reticulata. III. Memory-contingent visual and saccade responses. J Neurophysiol. 49:1268-84.
Original Literature Readings for discussion on November 19.
Schultz W (1986) Activity of pars reticulata neurons of monkey substantia nigra in relation to motor, sensory, and complex events. J Neurophysiol 55:660-77. Kawagoe R, Takikawa Y, Hikosaka O (1998) Expectation of reward modulates cognitive signals in the basal ganglia. Nat Neurosci 1:411-6. Laplane D, Levasseur M, Pillon B, Dubois B, Baulac M, Mazoyer B, Tran Dinh S, Sette G, Danze F, Baron JC (1989) Obsessive-compulsive and other behavioural changes with bilateral basal ganglia lesions. A neuropsychological, magnetic resonance imaging and positron tomography study. Brain 112:699-725. Middleton FA, Strick PL (1996) The temporal lobe is a target of output from the basal ganglia. Proc Natl Acad Sci USA 93:8683-7.