Basal Ganglia

Nobel of the Week

  • 2000 - Arvid Carlsson, Paul Greengard and Eric R. Kandel "for their discoveries concerning signal transduction in the nervous system", focus on Carlsson.

    Introductory Readings for discussion on November 17.

  • Principles of Neuroscience (2000) eds. Kandel, ER, Schwartz, JH, and Jessell, TM. Chapter 43.

    Additional background reading - highly relevant to information presented in class:

  • Alexander GE, DeLong MR, Strick PL (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9:357-381.
  • Middleton FA (2002) Fundamental and clinical evidence for basal ganglia influences on cognition. In: Mental and Behavioral Dysfunction in Movement Disorders (M.A. Bedard et al., Eds), pp. 13-33, Human Press., Totowa, NJ.

    Original Literature Readings for discussion on November 17.

  • Crutcher MD, DeLong MR (1984) Single cell studies of the primate putamen. I. Functional organization. Exp Brain Res 53:233-43.
  • Crutcher MD, DeLong MR (1984) Single cell studies of the primate putamen. II. Relations to direction of movement and pattern of muscular activity. Exp Brain Res. 53:244-58.
  • DeLong MR, Crutcher MD, Georgopoulos AP (1985) Primate globus pallidus and subthalamic nucleus: functional organization. J Neurophysiol. 53:530-43.
  • Hikosaka O, Wurtz RH (1983) Visual and oculomotor functions of monkey substantia nigra pars reticulata. III. Memory-contingent visual and saccade responses. J Neurophysiol. 49:1268-84.

    Original Literature Readings for discussion on November 19.

  • Schultz W (1986) Activity of pars reticulata neurons of monkey substantia nigra in relation to motor, sensory, and complex events. J Neurophysiol 55:660-77.
  • Kawagoe R, Takikawa Y, Hikosaka O (1998) Expectation of reward modulates cognitive signals in the basal ganglia. Nat Neurosci 1:411-6.
  • Laplane D, Levasseur M, Pillon B, Dubois B, Baulac M, Mazoyer B, Tran Dinh S, Sette G, Danze F, Baron JC (1989) Obsessive-compulsive and other behavioural changes with bilateral basal ganglia lesions. A neuropsychological, magnetic resonance imaging and positron tomography study. Brain 112:699-725.
  • Middleton FA, Strick PL (1996) The temporal lobe is a target of output from the basal ganglia. Proc Natl Acad Sci USA 93:8683-7.